Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Cover of: Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity. | National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .

Written in English

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  • Carcinogens.,
  • Fungicides -- Toxicology.

Edition Notes

Book details

SeriesCarcinogenesis technical report series ; no. 155, DHEW publication ; no. (NIH) 79-1711, National Cancer Institute carcinogenesis technical report series -- no. 155., DHEW publication -- no. (NIH) 79-1711.
The Physical Object
Paginationx, 115 p. :
Number of Pages115
ID Numbers
Open LibraryOL17538166M

Download Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity.

Bioassay of 2, 4, 6-trichlorophenol. for possible carcinogenicity cas no 2 nci-cg-tr u.s. departmen of healtht education, an,d welfare public healt servich e national institute of healts h. bioassay of. 2,4,6-trichlorophenol. for possible carcinogenicity.

Genre/Form: Online book: Additional Physical Format: Print version: National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity.

Note: Citations are based on reference standards. However, formatting rules can vary widely between applications and fields of interest or study.

The specific requirements or preferences of your reviewing publisher, classroom teacher, institution or organization should be applied. Summary of bioassay of 2,4,6-trichlorophenol for possible carcinogenicity (CAS No. ) [feed study]. NCI TR () 2,4,6-Trichlorophenol, a germicidal agent used to preserve wood and glue as well as protect textiles against mildew, was apparently discontinued production in in the United States because of high cost of removing dioxin by: NCI () Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity, Technical Report Series No.DHEW Publication No.

(NIH)DREW, Washington, DC. Onfelt, A. () Mechanistic aspects on chemical induction of spindle disturbances and abnormal chromosome numbers, Mutation Res.,Cited by: Jun 27,  · 2,4,6-Trichlorophenol: Target Organs and Levels of Evidence for TR Bioassay of 2,4,6-Trichlorophenol for Possible Carcinogenicity (CASRN ) Chemical (Study Title).

2,4,6- Trichlorophenol has been shown to be carcinogenic in animals, producing lymphomas, leukemia, and liver cancer via oral exposure. EPA has classified 2,4,6-trichlorophenol as a Group B2, probable human carcinogen.

Evidence for carcinogenicity to animais (inadequate for pentachlorophenol and 2,4,5-trichlorophenol; sufficíent for 2,4,6-trichlorophenol) Pentachlorophenol was tested in one ex periment in two strains of mice and in one experiment in rats by oral administration at dose levels sufficiently high to cause mild.

2,4,6-trichlorophenol is a trichlorophenol with phenolic substituents on positions 2, 4 and 6. It has a role as a carcinogenic agent. It is a conjugate acid of a 2,4,6-trichlorophenolate. 2,4,6-trichlorophenol appears as yellow to pinkish-orange needles or orange fluffy solid.

In animal models, Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity. book of 2,4,6-trichlorophenol leads to an increased incidence of lymphomas, leukemia, and liver cancer. It is classified as Group B2 (probable human carcinogen) by the United States Environmental Protection hamptonsbeachouse.comg point: °C ( °F; K) at 28 torr.

Adsorption of 2,4,6-trichlorophenol by multi-walled carbon nanotubes as affected by Cu(II) Article (PDF Available) in Water Research 43(9) · April with 99 Reads How we measure 'reads'. Books to Borrow. Top American Libraries Canadian Libraries Universal Library Community Texts Project Gutenberg Biodiversity Heritage Library Children's Library.

Open Library. test Halesowen Chronicle Newspaper Harlow Star Newspaper Mk News Newspaper Kidderminster Chronicle Newspaper Books by Language Additional Search Tips. Phrase Searching You can use double quotes to search for a series of words in a particular order. For example, "World war II" (with quotes) will give more precise results than World war II (without quotes).

Wildcard Searching If you want to search for multiple variations of a word, you can substitute a special symbol (called a "wildcard") for one or more letters. These data are, however, inadequate for a proper assessment of the carcinogenicity of these chlorophenols.

In a National Cancer Institute bioassay, 50 male and 50 female rats were administered either or 10 ppm 2,4,6-TCP (96 to 97% pure) in their diet for or weeks. 2,4,6-trichlorophenol MSDS report, 2,4,6-trichlorophenol MSDS safety technical specifications search, 2,4,6-trichlorophenol safety information specifications ect.

Author(s): Frederick Cancer Research Center.; National Institutes of Health (U.S.); Carcinogenesis Testing Program (U.S.) Title(s): Bioassay of 2, 4, 6.

ppm of 2,4,6-trichlorophenol for weeks. Female mice were initially administered 10, or 20, ppm of 2,4,6-trichlorophenol in feed. As the animals were observed to have decreased body weights, these concentrations were lowered to and ppm at week 38 (TWA dose =.

The Carcinogenesis Bioassay in Perspective: Application in Identifying Human Cancer Hazards Article (PDF Available) in Environmental Health Perspectives () · July with 36 Reads.

Bioassay of tetrachlorvinphos for possible carcinogenicity Bioassay of tetrachlorvinphos for possible carcinogenicity by United States.

National Cancer Institute. Carcinogen Bioassay and Program Resources Branch. Publication date Topics Carcinogens, Pesticides Publisher. Regulatory agencies currently rely on rodent carcinogenicity bioassay data to predict whether or not a given chemical poses a carcinogenic threat to humans.

We argue that it is always more useful to know a chemical's carcinogenic potency (with confidence limits) than to be able to say only qualitatively that it has been found to be a by: May 22,  · The choice of investigation mostly depends on the properties of the drug and/or the specific results obtained from long-term carcinogenicity testing.

Short or medium-term rodent models (See section "Short or medium- term [alternative] models in carcinogenicity bioassay") providing mechanistic insight into carcinogenic endpoints are also used. Search for books, ebooks, and physical Bioassay of malaoxon for possible carcinogenicity Published: () Bioassays of DDT, TDE, and p, p'-DDE for possible carcinogenicity Published: () Bioassay of dixathion for possible carcinogenicity Published: ( National Cancer Institute (NCI) () Bioassay of 2,4,6-trichlorophenol for possible carcinogenicity.

NIH Publication No. National Cancer Institute, Bethesda Google Scholar Parra S, Malato S, Pulgarin C () New integrated photocatalytic-biological flow system using supported TiO 2 and fixed bacteria for the mineralization of Cited by: McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W.

Responses of the LY tk+/tk- mouse lymphoma cell forward mutation. NTP. TR 2,4,6-Trichlorophenol (). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

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A bioassay of hexachlorophene for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer rats. Groups of 24 rats of each sex were administered hexachlorophene at one of three doses, either 17, 50, or ppm, for weeks.

Higher doses of ppm, used in 8-week subchronic. The conventional test for carcinogenicity is the long-term rodent carcinogenicity bioassay described in Organisation for Economic Cooperation and Development (OECD) Test Guideline (TG) The objective of this test is “to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after.

The only investigation of the subchronic oral toxicity to animals of 2,4,6-trichlorophenol was a range-finding experiment by the NCI () preliminary to performing an oral carcinogenicity bioassay.

In this study, groups of five male and five female Fischer rats were fed ad. libitum diets that contained 0, 10, 14, 21, 31, or.

The CAG evaluates substances for possible carcinogenicity according to the procedures outlined in the Agency's Interim Guidelines for Carcinogen Risk Assessment found in Interim Procedures and Guidelines for Health Risk and Economic Impact Assessments of Suspected Carcinogens (41 Fed.

Reg. May 25, ). The minority of the committee believes that the process for selecting doses to be used in a carcinogenicity bioassay should be modified. Specifically, the minority recommends that dose selection be done by a panel of experts on the basis of careful evaluation of appropriate subchronic studies conducted before the bioassay is initiated.

Bioassay of 1,2-dichloroethane for possible carcinogenicity. Format Book Published Bethesda, Md.: Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing.

Mar 01,  · In this commentary, I summarize carcinogenesis results for several chemicals used in the wood industry, as well as for wood dust.

Findings from experimental carcinogenesis studies in animals are not only important for ascertaining or confirming carcinogenic risks to humans () but for planning and performing etiologic epidemiologic studies as well (6). 2,4,6-tribromophenol >98 Section 4 - FIRST AID MEASURES SWALLOWED IF SWALLOWED, REFER FOR MEDICAL ATTENTION, WHERE POSSIBLE, WITHOUT DELAY.

Where Medical attention is not immediately available or where the patient is more than 15 minutes from a hospital or unless instructed otherwise: For advice, contact a Poisons Information Center or.

BIOASSAY OF FLUOMETURON FOR POSSIBLE CARCINOGENICITY Carcinogenesis Testing Program National Cancer Institute and National Toxicology Program Research Triangle Park FOREWORD This report presents the results of the bioassay of fluometuron con-ducted for the Carcinogenesis Testing Program, National Cancer Institute (NCI), National Toxicology.

Carcinogenicity (IARC Classification) 2B, possibly carcinogenic to humans. Uses/Sources: 2,4,6-Trichlorophenol has been used as a fungicide, herbicide, insecticide, antiseptic, defoliant, and glue preservative.

Skin contact while treating wood with the tetrachlorophenols is the Accession Number: T3D Although 2,4,6-trichlorophenol is a carcinogen in lifetime rodent studies, no evidence was found for DNA damage in rat liver or the white cells of rat blood. Similiarly no compound related changes were found in serum alanine aminotransferase, hepatic glutathione or cytochrome P content.

Apr 07,  · Hexachloroethane is classified as a possible human carcinogen by IARC and is reasonably anticipated to be a human carcinogen by NTP. The U.S. EPA has established drinking water and other environmental regulations for hexachloroethane. Workplace standards and guidelines for hexachloroethane have been established by OSHA and ACGIH, respectively.

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Below is the uncorrected machine-read text. standards, which covers genotoxicity, carcinogenicity, and reproductive toxicity, describes carcinogenicity testing as the means "to determine the tumorigenic potential of devices, materials, and/or extracts to.

Bioassays Bioassays are experiments that use living things to test the toxicity of chemicals. Students can use bioassays to conduct a wide range of experiments relating to toxicity of known chemical solutions or unknown mixtures such as samples of water, sediment, or soil from the environment.Bioassay of selenium sulfide for possible carcinogenicity (dermal study) [] National Cancer Institute (U.S.).

Bethesda, Md.: Dept. of Health and Human Services, Public Health Service, National Institutes of Health, Apr 01,  · Sponsor a Book. Edit. Last edited anonymously. April 1 Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity by National Cancer 2 editions - first published in Not in Library.

Bioassay of fluometuron for possible carcinogenicity by National Cancer Institute (U.S.) 2 editions - first.

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